Endocrine Abstracts

Background: Immune checkpoint inhibitors (ICIs) are approved for the treatment of non-small cell lung cancer (NSCLC) and are associated with specific immune-related adverse events (iRAEs) including endocrine toxicities. However, data concerning the type, occurrence, and dynamics of iRAEs and their predictive value on treatment outcome are lacking. In this study, we evaluated the relation of iRAEs to anti-PD/L1 (programmed cell death protein/ligand-1) ICIs focusing particularly...

Background: Polycystic ovary syndrome (PCOS) is associated with features linked to metabolic syndrome including visceral adiposity, dyslipidemia and impaired glucose homeostasis. Adipose tissue produces adipocytokines which contribute to regulation of insulin sensitivity and reproduction. Omentin-1 is an adipokine with anti-inflammatory and insulin sensitizing roles produced by adipocytes. The exact role of mentin-1 in PCOS remains unclear as studies have reported reduced or u...

Case history: An 18-year-old Caucasian female presented with primary amenorrhoea after her younger sister aged 16 years old started menstruating. She had a normal childhood and progressed through puberty normally, with no past medical history or family history. BMI was 22.6 with a normal examination including secondary sexual characteristics (Tanner Stage 5) and no signs of hyperandrogenism.Investigations and Results: Bloods showed an elevated LH:FSH rat...

Introduction: Familial Partial Lipodystrophy Type 1 (FPLD1) is characterised by loss of gluteal and limb subcutaneous fat and increased abdominal fat. The genetic basis is currently unknown. FPLD1 is frequently associated with metabolic problems including diabetes, insulin resistance, dyslipidaemia and non-alcoholic fatty liver disease. Despite central adiposity and severe metabolic abnormalities, this group of patients often do not qualify for NHS funding for bariatric surger...

Background: Kisspeptin stimulates gonadotropin secretion indirectly by stimulation of hypothalamic GnRH neurons. Kisspeptin and kisspeptin receptor, a G-protein coupled receptor (GPCR), are also expressed in the human ovary, but their direct actions on ovary, if any, are unclear.Objectives: To examine the direct actions of kisspeptin on granulosa lutein cells (GL cells) and the role of kisspeptin in steroidogenesis.Materials and me...

Background: Current guidelines recommend regular monitoring of total testosterone, haematocrit and prostate-specific antigen (PSA) when androgen-deficient males are commenced on testosterone replacement therapy (TRT). The aim is to restore serum total testosterone to the mid-normal range, whilst maintaining haematocrit and PSA at the recommended levels. Limited studies have assessed the impact of ethnicity on these biochemical parameters.Aim: To measure ...

Non-healing foot ulcers are a major complication in diabetic patients. Mesenchymal stem cells (MSCs) are known to promote angiogenesis with improved wound healing. Orbsen Therapeutics has identified a novel antibody (CD362+) which can be used to prospectively FACS-isolate CD362+CD45− MSC from human bone marrow with enhanced MSC/MNC purity ratios of up to 1/4. Excellagen matrix was used to seed the cells as biomaterials are well reported t...

Introduction: Patients with MEN1 have increased morbidity and mortality compared to those patients with sporadic NETs. No genotype-phenotype correlation is described and age-related clinical penetrance surpasses 50 and 90% by 20 and 40 years, respectively. The aim of the audit was to compare the screening programme for MEN1 patients with MEN1 clinical guidelines.Methods: Case notes of MEN1 patients attending a tertiary NET-multidisciplinary team (MDT) in...

Background: The PAOLA study assessed the efficacy/safety of pasireotide LAR vs continued treatment with octreotide LAR/lanreotide Autogel in patients with inadequately controlled acromegaly. An exploratory objective was to measure changes in various associated biomarkers, including IGF1 and IGFBP2 (released from white fat cells and known to prevent insulin resistance), glucose and HbA1c.Methods: Adult patients (GH >2.5 μg/l and IGF1 >1.3&#21...

Background: There are no effective blood biomarkers for bronchopulmonary carcinoids (BPC). We examined the utility of a neuroendocrine multigene transcript ‘liquid biopsy’ (NETest) in bronchopulmonary carcinoids (BPC) for diagnosis and monitoring of disease status.Aim: To independently validate the utility of the NETest in diagnosis and management of BPC in a prospective multicenter, multinational blinded study.Material a...